Physicians may also prescribe clomiphene for use alongside TRT.
Interestingly some in the medical field believe it to be a viable alternative to raise testosterone levels in place of TRT altogether.
Clomiphene can successfully stimulate the hypothalamus to cause increased testicular testosterone production
Stimulation with 50 mg of oral clomiphene three times weekly may be diagnostic as well as therapeutic.
If the patient does not respond with at least a 75% increase in testosterone and a 100% increase in Luteinizing hormone.
Should it fail to raise hormone levels, further evaluation of the hypothalamic-pituitary area is warranted.
To understand how it works, you need to know how the pituitary controls the making of testosterone in the testis.
Testosterone is made by Leydig cells in the testis.
The pituitary releases a hormone called luteinizing hormone (“LH”) that stimulates the Leydig cells to produce testosterone.
Testosterone is converted to the female hormone estrogen.
Then estrogen tells the pituitary to stop making more LH.
This kind of negative feedback system is typical when it comes to how hormones work.
It’s just like a thermostat and heater.
As it gets warmer, the signal to stop producing heat is sent by the thermostat.
When heater gets cool, the switch is tripped to provide more heat.
By blocking estrogen at the pituitary the pituitary gland will make more Luteinizing Hormone (LH).
What that means is that now the Leydig cells in the testis will make more testosterone.
Uses for clomiphene in men
In the case of injectable testosterone, the pituitary gets the signal that there is too much and luteinizing hormone takes a dive.
Clomiphene (Clomid) is proven to increase testosterone levels along with the sie aat the same time while preserving testis size and function.
Clomiphene is finding more use as a therapy for younger men due to the absence of concerns about fertility.
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