LGD-4033 (Ligandrol / Anabolicum) 1000 mg

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LGD-4033 (Ligandrol) in a phase I single ascending-dose study had established the safety of up to 22 mg.

This SARM a reputation for building muscle and burning fat.

The LGD-4033 Review 

Description: LGD4033, also known as VK5211 and Ligandrol, is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting and osteoporosis.

Currently, it is under development by Ligand Pharmaceuticals.

From all accounts, this drug was safe and had a favorable pharmacokinetic profile.

LGD-4033 is known to many as one of the best muscle building SARMS available.

Originally it had been investigated for use in fractures and muscle wasting conditions.

The LGD-4033 reviews by users have earned this SARM a reputation for building tons of muscle and not much fat. 

The reported effects claim it is best for bulking up on lean body mass.

Selective androgen receptor modulators (SARMS) are novel non-steroidal oral drugs that bind to muscle and bone receptors.

SARMS are in a new class of androgen receptor (AR) ligands that are tissue-selective.

LGD-4033 has been used in 21-day clinical trials to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss.

The results were as expected and produced the therapeutic benefits of testosterone with improved muscle tissue, fat loss, safety, tolerability and patient acceptance due to an oral route of administration.

 

LGD-4033 dosages in the range of

  • 0.1 mg/day 
  • 0.3 mg/day
  • 1.0 mg/day

were selected for multiple dosing over 21 days period.

A previous phase I single dose study had established the safety of up to 22 mg.

Pretty darned low doses for anything, LGD-4033 is a powerhouse of a SARM.

This study was a double-blind, placebo-controlled, multiple once-daily dose escalation study of LGD-4033 in healthy men.

This had been approved by Boston University’s Institutional Review Board.

All subjects provided written informed consent.

LGD-4033 results

SARMS LGD-4033 is an oral selective androgen receptor modulator that produces excellent results similar to Dianabol.

With such low daily dosages, there seem to be many fewer side effects than with anabolic steroids. 

While Viking therapeutics (ligand pharmaceuticals) is working on LGD's replacement, many researchers are adding tons of lean muscle mass and lost body fat in a short period with the effects of LGD-4033.

Interesting to note is that the dosage is far below the normal mg day dosing that anabolic steroid will require.

Is it just muscle growth or preventing muscle breakdown that will interest the researcher?

 

LGD-4033 results have been interpreted as safe.

With a favorable pharmacokinetic profile, it increased lean body mass even during the short 21 day period.

All this without a change in the prostate-specific antigen.

Lean Body Mass (LBM) increased dose-dependently with averaging 1.21 kg at the 1.0-mg dose vs. placebo.

Continued research has yielded remarkable results on par with the likes of testosterone therapy.

SARMS Review

Selective Androgen Receptor Modulators (SARMs) are a class of androgen receptor ligands that bind the androgen receptor and display tissue-selective activation of androgenic signaling.

The initial efforts to develop steroidal SARMs, based on modifications of the testosterone molecule, date back to the 1940s.

The modern era of nonsteroidal SARMs was unleashed by independent work at Ligand Pharmaceuticals.

Pioneering efforts by scientists at Ligand Pharmaceuticals and the University of Tennessee provided the early foundations of the nonsteroidal SARM discovery.

Since then, several basic categories of SARM pharmacophores have been explored.

As only a fraction of the discovery research has been published, it is likely that additional structural categories exist.

A recent review by Narayanan et al. provides an excellent treatise of the SARM structures.  

SARMSPHARM

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Name: LGD-4033 (Ligandrol) 
CAS#: 1165910-22-4 
Chemical Formula: C14H12F6N2O 
Exact Mass: 338.08538 
Molecular Weight: 338.25 
Elemental Analysis: C, 49.71; H, 3.58; F, 33.70; N, 8.28; O, 4.73

All products listed and provided through our website are intended for research purposes only. We do not promote the personal use of these products. Products and services provided by 99SARMS.com are not intended for use in food products or as any drug. Our products are not intended to treat, prevent, mitigate or cure any disease or medical condition.

Customer reviews
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  • Mikeo Heseltine
    Mar 31, 2019, 21:42
    LGD 4033 is all that it raved up to be! I may sound bias but it’s my favourite compound that I’ve used and in my short two year stint I’ve used a few!
    LGD4033 is my favourite compound because it honestly gives the same effect as anadrol.. but minimal if any sides ... I ran LGD at 10-20mg daily for 8/9 months sarms cycle with minimal suppression on the other hand I ran anadrol 50mg pre workout for 100 days and suffered laboured breathing and joint pain heightened blood pressure

    While running lgd I gained size and strength noticeably quickly and felt healthy and great doing it there is no doubt to this sarms capability and it can only get better stacking it with other sarms like RAD140 or S23 for some really serious size and strength gains! I could go on for days about this compound ... but I think you get what I’m saying!
  • Adam Moyer
    Feb 23, 2019, 10:10
    Great product that provides great result, combined with Rad140 i got a nice lean more full look, strength and endurance increased noticeably. Love LGD

Product questions

  • Chris
    Apr 9, 2019, 15:52

    What is the dosage for a 138lb female?

    Administrator
    Apr 9, 2019, 16:28

    Results have been interpreted as safe, had a favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in the prostate-specific antigen. LBM increased dose-dependently with the increase in LBM averaging 1.21 kg at the 1.0-mg dose vs. placebo. However these products are not for human consumption please refer https://www.99sarms.com/terms-of-service.html

    A phase I single ascending-dose study had established the safety of up to 22 mg. Pretty darned low doses for anything, this is the clue to just how powerful LGD may be.

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