UDCA 20 grams for treatment of liver disease or support also has off label use in cystic fibrosis, gallstones, treatment in diabetes via increasing insulin sensitivity. Orange spoon 400mg white dosing spoon 120mg
Buy UDCA Liver Powder 400mg spoon included
Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. Aside from liver disease or liver support it has also found much needed off label use in cystic fibrosis treatment, dissolution of gallstones, treatment in diabetes via increasing insulin sensitivity thereby lowering scores for insulin resistance.
UDCA Case study
Oral 17 alpha alkylated steroids cause Drug-Induced Liver Injury (DILI). It should be stressed that if one develops the symptoms of drug-induced cholestasis, the first line of treatment is to immediately discontinue the drug. In the case of oral AAS the prognosis is good and once therapy begins the disease usually resolves.
"A 28-year-old body builder was admitted because of jaundice. For 80 days, until three weeks before hospitalization, he had been taking moderately high doses of anabolic steroids: Dianabol or D-Bol (methandienone), 10-50 mg daily by mouth, and stanozolol, 50 mg intramuscularly every other day. Physical examination was unremarkable except for yellow discoloration of the skin and sclerae...Liver biopsy was compatible with cholestasis induced by anabolic steroids...The patient's state improved simultaneously with the administration of ursodeoxycholic acid UDCA and the biochemical values gradually reached normal levels after several weeks. CONCLUSION: Anabolic steroids can cause severe cholestasis and acute renal failure. In this case, there was a notable temporal coincidence between the administration of ursodeoxycholic acid and the marked clinical improvement."
How UDCA works
Ursodeoxycholic acid (UDCA) is a chemical called a bile acid. It occurs naturally in bile and can be used to dissolve gallstones. The liver produces bile that is stored in the gall bladder. Bile is released by the gall bladder to aid the digestion of fats. It consists of cholesterol dissolved within bile salts. Gallstones occur in the gall bladder as a result of too much cholesterol, or too few bile salts within the bile. The imbalance causes excess cholesterol to separate of the bile and form stones. Ursodeoxycholic acid causes gallstones to dissolve by a mechanism that is not fully understood. It is known to reduce the production of cholesterol by the liver and also to reduce the absorption of cholesterol from the gut. Both of these actions decrease the amount of cholesterol that passes into the bile. Also, since ursodeoxycholic acid is a bile acid itself, it increases the level of bile acids within the bile. The combination of these two factors reverses the imbalance and stops the cholesterol separating of the bile. The gallstones then begin to dissolve.
Besides existing in its natural form, UDCA has been synthesized, and all pharmaceutical formulations are synthetic. Besides dissolving gallstones, UDCA exerts other actions of more interest to AAS using bodybuilders. Oral 17 alpha alkylated steroids often cause a condition called cholestasis. Cholestasis is any condition in which bile excretion from the liver is blocked, which can occur either in the organ where bile is formed or in the bile ducts.
UDCA is still the only approved treatment for primary biliary cirrhosis (liver disease).
UDCA vs. TUDCA
Buy ursodeoxycholic acid UDCA if quality control and USP grade designation are vital to your work. Aside from chronic liver disease off label use in cystic fibrosis, gallstones and for diabetics as a method of improving insulin resistance. UDCA Ursodeoxycholic acid in the treatment for intrahepatic cholestasis of pregnancy may be used, and this is due to low or lack of side effects.
TUDCA tauroursodeoxycholic acid
TUDCA is now a supplement and appears to be everywhere. Tauroursodeoxycholic acid tudca is a newer version of UDCA. TUDCA big claim to fame is that it has increased absorption yet it's only valid claim is that it is a supplement and not a treatment for anything.
I do not want to BASH TUDCA I think it is pretty good for what it is. What I do not buy is that it is as good or better than UDCA. I will give you my reasons as follows:
- UDCA ursodeoxycholic acid is still the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and delaying of liver transplantation.
- PRICE is definitively the reason for my suspicions. To whit that is the actual cost to synthesis TUDCA is nearly double the value of UDCA. UDCA is already Uber expensive in its own right! I cannot make numbers work in any available TUDCA supplements considering the exorbitant cost to make it and the extra cost to encapsulate and bottle the supplement.
- The Sale Price of various TUDCA supplements online by my survey tells me two things
- TUDCA supplements are of either aa low food grade standard and not USP grade or
- Supplement Marketers are either pulling a fast one on TUDCA consumers as a whole and not delivering pure products or some other kind of sales trickery is going on. This all too common in the loosely regulated supplement racket and my money is on TUDCA will be no exception.
I want to make no misrepresentations or SLAM any supplement company; the blame lays square on the manufacturer at contract level by huge organizations. They run the industry from behind the curtain; they are the ones that source ingredients, encapsulate, bottle and label supplements for all brands.
Why not buy TUDCA?
Ask yourself this one question, why doesn't Mark Glazier of Nutrabio carry TUDCA? This is one guy and the only guy WHO WILL NEVER BEND ON THE ABSOLUTE HIGHEST QUALITY SUPPLEMENTS. I buy all my supplements from NUTRABIO, and they do not carry TUDCA.
TUDCA vs. UDCA we would love to have your comments and opinions on this piece.